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Thus, the pathway involving Loc100506691 and CHAC1 presents a potential target for therapeutic intervention in gastric cancer, leveraging metformins regulatory impact on this lncRNA (Tseng et al., 2021)

GLP-1R activation, however, has no significant impact on insulin-like growth factor 1 (IGF-1), IGF binding protein 1 (IGFBP1), or insulin levels in fetal circulation

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Because KLRG1 is widely used as a marker of highly activated, cytokine-producing ILC2s (66, 67), this finding supports the idea that melatonin drives a phenotypic transition from an activated, KLRG1 high effector state toward a more quiescent, KLRG1 low phenotype

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